Visible-Light-Mediated Decarboxylative Benzylation of Imines with Arylacetic Acids

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Visible-Light-Mediated Decarboxylative Benzylation of Imines with Arylacetic Acids

Guo, Jing; Wu, Qiao-Lei; Xie, Ying; Weng, Jiang; Lu, Gui

Journal of organic chemistry, 10/2018, Volume: 83, Issue: 20

Journal Article

A straightforward method for the visible-light-mediated decarboxylative benzylation of imines is reported. The key feature of this method is the use of simple primary, secondary, and tertiary arylacetic acids as precursors of benzyl radicals, enabling the facile benzylation of a variety of imines under mild conditions. A variety of structurally diverse β-arylethylamines (37 examples) was accessed using this method.

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Guo, Jing | Wu, Qiao-Lei | Xie, Ying | Weng, Jiang | Lu, Gui

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