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Masuda, Norikazu; Lee, Soo-Jung; Ohtani, Shoichiro; Im, Young-Hyuck; Lee, Eun-Sook; Yokota, Isao; Kuroi, Katsumasa; Im, Seock-Ah; Park, Byeong-Woo; Kim, Sung-Bae; Yanagita, Yasuhiro; Ohno, Shinji; Takao, Shintaro; Aogi, Kenjiro; Iwata, Hiroji; Jeong, Joon; Kim, Aeree; Park, Kyong-Hwa; Sasano, Hironobu; Ohashi, Yasuo; Toi, Masakazu
The New England journal of medicine, 06/2017, Volume: 376, Issue: 22Journal Article
Patients who complete neoadjuvant chemotherapy for breast cancer without a pathological complete response have a high risk of relapse. A randomized trial comparing capecitabine with no additional adjuvant therapy showed that capecitabine prolonged disease-free and overall survival. Patients who have residual invasive breast cancer after the receipt of neoadjuvant chemotherapy have a high risk of relapse. 1 The rate of complete response as assessed on pathological testing (hereafter, pathological complete response) ranges from 13 to 22% among patients with human epidermal growth factor receptor 2 (HER2)–negative primary breast cancer. 1 Patients who do not have a pathological complete response after the receipt of neoadjuvant taxane and anthracycline chemotherapy have a 20 to 30% risk of relapse. 2 Patients with HER2-negative cancer who receive neoadjuvant chemotherapy often receive postoperative radiation therapy, whereas endocrine therapy is administered to patients with hormone-receptor–positive disease . . .
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