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Brock, Penelope R; Maibach, Rudolf; Childs, Margaret; Rajput, Kaukab; Roebuck, Derek; Sullivan, Michael J; Laithier, Véronique; Ronghe, Milind; Dall’Igna, Patrizia; Hiyama, Eiso; Brichard, Bénédicte; Skeen, Jane; Mateos, M. Elena; Capra, Michael; Rangaswami, Arun A; Ansari, Marc; Rechnitzer, Catherine; Veal, Gareth J; Covezzoli, Anna; Brugières, Laurence; Perilongo, Giorgio; Czauderna, Piotr; Morland, Bruce; Neuwelt, Edward A
The New England journal of medicine, 06/2018, Volume: 378, Issue: 25Journal Article
Cisplatin is an effective treatment for hepatoblastoma but often leads to lifelong irreversible hearing loss. The addition of sodium thiosulfate 6 hours after cisplatin administration preserved the antitumor effect and led to a lower risk of hearing loss (33% vs. 63%).
