Digital Therapeutics to Enhance Cognition in Major Depression: How Can We Make the Cognitive Gains Translate Into Functional Improvements?

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Digital Therapeutics to Enhance Cognition in Major Depression: How Can We Make the Cognitive Gains Translate Into Functional Improvements?

Harvey, Philip D.

The American journal of psychiatry, 07/2022, Volume: 179, Issue: 7

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Harvey discusses the clinical trial by Keefe et al with several important features. The study examines the efficacy of a technology-based intervention, "AKL-T03," which is a multitasking video intervention in which participants simultaneously respond to or ignore stimuli based on prior instruction while navigating in space to approach or avoid these designated targets or nontargets. Immediate functional gains on self-report measures were not detected despite cognitive gains in the active training group. Like the results of the Mahncke et al study, short-term cognitive gains did not translate into detectable functional changes.

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