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Kalogera, Eleftheria; Nevala, Wendy K; Finnes, Heidi D; Suman, Vera J; Schimke, Jill M; Strand, Carrie A; Kottschade, Lisa A; Kudgus, Rachel A; Buhrow, Sarah A; Becher, Laura R; Geng, Liyi; Glaser, Gretchen E; Grudem, Megan E; Jatoi, Aminah; Klampe, Carolyn M; Kumar, Amanika; Langstraat, Carrie L; McWilliams, Robert R; Wahner Hendrickson, Andrea E; Weroha, S John; Yan, Yiyi; Reid, Joel M; Markovic, Svetomir N; Block, Matthew S
Clinical cancer research, 06/2024, Volume: 30, Issue: 12Journal Article
AB160 is a 160 nm nano-immunoconjugate consisting of nab-paclitaxel (ABX) nanoparticles non-covalently coated with bevacizumab (BEV) for targeted delivery into tissues expressing high levels of VEGF. Preclinical data showed that AB160 resulted in greater tumor targeting and tumor inhibition compared to sequential treatment with ABX then BEV. Given individual drug activity, we investigated the safety and toxicity of AB160 in patients with gynecologic cancers. A 3+3 phase I trial was conducted with 3 potential dose levels in patients with previously treated endometrial (EC), cervical (CC), and platinum-resistant ovarian cancer (OC) patients to ascertain the recommended Phase II dose (RP2D). AB160 was administered intravenously on Days 1, 8 and 15 of a 28-day cycle (ABX 75-175 mg/m2, BEV 30-70 mg/m2). Pharmacokinetic analyses were performed. No dose-limiting toxicities (DLTs) were seen among the 3 DLs tested. Grade 3/4 toxicities included neutropenia, thromboembolic events, and leukopenia. DL2 (ABX 150 mg/m2, BEV 60 mg/m2) was chosen as the RP2D. Seven of the 19 patients with measurable disease (36.8%) had confirmed partial responses (95% CI: 16.3%-61.6%). Pharmacokinetic analyses demonstrated that AB160 allowed 50% higher paclitaxel dosing and that paclitaxel clearance mirrored that of therapeutic antibodies. The safety profile and clinical activity of AB160 supports further clinical testing in patients with gynecologic cancers; the RP2D is DL2 (ABX 150 mg/m2, BEV 60 mg/m2).
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