Antimicrobial peptides (AMPs) are a class of novel bio-molecules with broad-spectrum antibacterial properties and have attracted interest due to rapidly increasing antibiotic resistance. LL37 is the only cathelicidin-derived antimicrobial peptide found in humans. With the in-depth researches, LL37 has been shown to exhibit various bio-functions including regulation of the inflammatory response, chemotaxis of immune cells, promotion of wound healing, osteogenesis, which encourage a variety of clinical applications. While the clinical translation of LL37 is opposed by its susceptibility to protease degradation, potential toxicity, poor bioavailability and other limitations. Various delivery systems are introduced including metal nanoparticles, polymeric materials and lipids-based systems, to realize the therapeutic applications. In this review, we aim to report current researches of delivery systems for LL37 and hope to aid the future related work. Display omitted •LL37 has been shown to exhibit various bio-functions which encourage its potential clinical applications.•The clinical translation of LL37 is opposed by its innate drawbacks such as susceptibility to protease degradation and potential toxicity.•Various delivery systems are introduced to realize the therapeutic applications of LL37.