Epidemic outbreaks are often accompanied by the unconfirmed information propagation Especially in the early stages of an epidemic outbreak, because of the lack of adequate verification, some unconfirmed information appears, which has a significant impact on the epidemic. Meanwhile, individuals under different emotions can also have different response to epidemics. In the paper, an interplay between epidemic spreading and unconfirmed information propagation model is established considering individuals’ emotional factors in multilayer networks. The mean-field method is used to analyze the interaction dynamic propagation process and the threshold of epidemic is obtained. Finally through the theoretical analysis and numerical simulations of scale-free network, the validity of the results is verified. The results show that the information, although unconfirmed, is still conducive to curb the spread of the epidemic. In addition, individuals with different emotions will adopt different self-protective behaviors, so as to further affect the spread of the epidemic. •An interplay between unconfirmed information propagation and epidemic spreading model is proposed.•The individuals’ emotional factors are considered in multilayer network.•The mean-field method is used to analyze the interaction dynamic propagation process.•The unconfirmed information propagation have an effect on the spread of the epidemic.•The individuals with anxious make less favorable for the epidemic control.