Objective To close the chasm between theory about families containing a parent with an eating disorders (EDs) history and lack of selective or indicated prevention programming for such families with an older child or adolescent who is, genetically, at high risk. Method A search of four major databases for January 2000 through September 2022 yielded no publications that (a) identified genetically high‐risk families with offspring ages 10 through 18; (b) devised a prevention program for the family; and (c) evaluated program effects on risk/protective factors. To rectify this gap, research on three lines of family‐based prevention is reviewed: (1) programs for adolescents at genetic risk for depression or anxiety; (2) the Stanford‐Dresden project for adolescents at high risk for anorexia nervosa; and (3) Sadeh‐Sharvit et al.'s work concerning the Parent‐Based Prevention program for mothers with an EDs history and a child under age 5. Results The significant challenges for innovative prevention programming should be addressed by experts in effective EDs, depression, and anxiety prevention, and in family‐based treatment (FBT) for EDs, collaborating with people from genetically vulnerable families. Innovative programming should focus on robust risk factors for EDs, adaptive expression of non‐specific risk factors (e.g., temperament), and strengthening family functioning. Discussion The field is overdue for development of prevention programs designed for older children or adolescents who are at risk because a parent has an ED. Evidence‐based prevention programs for EDs and for depression and anxiety, as well as parent‐based prevention informed by FBT, provide a springboard for addressing this gap. Public Significance The foundation of theory and research is available for stakeholders to develop prevention programming that closes the huge gap between theory and research about families that are genetically vulnerable for eating disorders versus the complete lack of prevention programming for such families that have an older child or adolescent at high risk.