Versicolols A and B, two new prenylated isocoumarins from endophytic fungus Aspergillus versicolor and their cytotoxic activity

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Versicolols A and B, two new prenylated isocoumarins from endophytic fungus Aspergillus versicolor and their cytotoxic activity

Zhou, Min; Lou, Jie; Li, Yin-Ke; Wang, Yue-De; Zhou, Kun; Ji, Bing-Kun; Dong, Wei; Gao, Xue-Mei; Du, Gang; Hu, Qiu-Fen

Archives of pharmacal research, 2017/1, Volume: 40, Issue: 1

Journal Article

Versicolols A and B ( 1 and 2 ), two rare prenylated isocoumarin derivatives, along with five known isocoumarins ( 3 – 7 ) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor . Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. The results showed that compounds 1 exhibited weak cytotoxicity against A549 and MCF7 cells with IC 50 values of 9.4 and 8.8 μm, and compound 2 exhibited weak cytotoxicity against SHSY5Y and MCF7 cells with IC 50 values of 8.2 and 6.8 μm, respectively.

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