The possible entry of SARS‐CoV‐2 to reach the brain via cribriform plate (B) or after systemic circulatory dissemination following infection of the lung (C), in early or late phases of COVID‐19 may result in loss of involuntary control of breathing resulting in acute respiratory insufficiency requiring assisted ventilation (D) The clinicians throughout the world in general, and Wuhan, China, in particular, are getting the firsthand to study and report the real‐time clinical presentations of the patients affected by COVID‐19. The prognostic and diagnostic significance of neurological sign and symptoms in COVID‐19 patients can be gauged by fact that the protocol designed to investigate the First Few X cases (FFX) and their close contacts by the World Health Organization (WHO), includes a separate section for “other neurological signs” in addition to separate columns for respiratory symptoms. 3 Additionally, reports of COVID‐19‐affected individuals experiencing convulsions in prevalent areas is alarming and need to be distinguished from febrile convolution that is expected to occur with high‐grade fever in patients with COVID‐19. Studies believe that direct SARS‐CoV infection of the human CNS does occur in some patients. 8 It is also important to mention here that the neurological signs and symptoms observed in the COVID‐19 cases could be a manifestation of hypoxia, respiratory, and metabolic acidosis at an advanced stage of the disease, but reasonably, a differential diagnosis of these cases is needed, which could prove lifesaving.