In this study, a dispersive solid-phase extraction (DSPE) pretreatment procedure using zeolite H-Beta as a sorbent was exploited for the determination of eight neonicotinoids in bottled water and honey products based on ultra-high-performance liquid chromatography–tandem mass spectrometry analysis. The zeolite H-Beta was demonstrated to be a suitable sorbent for neonicotinoid insecticides, even after 10 recycles of reuse. The method performance was evaluated by the linearity (R2 ≥ 0.998), recovery (71–108%), precision (0.1–7.8%), limit of detection (0.05–0.1 ng/mL) and limit of quantification (0.1–0.2 ng/mL), which suggested excellent stability and high sensitivity with the use of the DSPE procedure. The method was further successfully applied in the test of neonicotinoid insecticides in 34 samples. Zeolite H-Beta shows promise as an efficient and practical material for monitoring neonicotinoid insecticides in bottled water and multiplex honey matrices.