Tetracycline hydrochloride (TCH) electro-oxidation by commercial DSA® and commercial DSA® modified by platinum electrodeposition was evaluated. The electrodeposition was carried out at constant potential ( E  = − 0.73 V vs RHE) in different times (1200, 2400, and 4800 s). Scanning electron microscopy (SEM) images show that Pt electrodeposits have elongated shape particle forming a uniform surface, and energy dispersive spectroscopy (EDS) data confirms the presence of Pt on the surface. The electrochemical characterization by cyclic voltammetry showed an increase of the electrochemically active area ( E AA ) in function of the Pt electrodeposition time. The electro-oxidation of the TCH 0.45 mmol L −1 in H 2 SO 4 0.1 mol L −1 solution was evaluated according to the applied current densities ( j  = 25, 50, 100 mA cm −2 ). Both the amount of platinum deposited and j showed a slight improvement in the efficiency of TCH removal, reaching 97.2% of TCH removal to DSA®/Pt 4800 and 100 mA cm −2 . The TCH mineralization (TOC removal), the percentage of mineralization current efficiency (MCE%), and energy consumption were 15.8%, 0.2649%, and 7.4138 kWh (g TOC) −1 , respectively. The DSA®/Pt electrodes showed higher stability to TCH electro-oxidation, indicating to be a promising material for the electro-oxidation of organic pollutants.