Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance

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Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance

Zhou, Mi; Kim, William Y

Clinical cancer research, 04/2023, Volume: 29, Issue: 7

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Clear-cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance. See related article by Lu et al., p. 1279.

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