After almost a year of COVID‐19, the chronic long‐COVID syndrome has been recognized as an entity in 2021. The patients with the long‐COVID are presenting with ominous neurological deficits that with time are becoming persistent and are causing disabilities in the affected individuals. The mechanisms underlying the neurological syndrome in long‐COVID have remained obscure and need to be actively researched to find a resolution for the patients with long‐COVID. Here, the factors like site of viral load, the differential immune response, neurodegenerative changes, and inflammation as possible causative factors are debated to understand and investigate the pathogenesis of neuro‐COVID in long‐COVID syndrome. The SARS‐CoV‐2 viral loads in nose are now known to reach the brain via cribriform plate. If the neurons in the CNS experience cellular degeneration due to SARS‐COV‐2, it is expected that patient with Long‐COVID syndrome would exhibit neurological deficits.