E-resources
Peer reviewed
-
Holz, Frank G., MD; Bindewald-Wittich, Almut, MD; Fleckenstein, Monika, MD; Dreyhaupt, Jens, PhD; Scholl, Hendrik P.N., MD; Schmitz-Valckenberg, Steffen, MD
American journal of ophthalmology, 03/2007, Volume: 143, Issue: 3Journal Article
Purpose To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age-related macular degeneration (AMD). Design Prospective longitudinal multicenter natural history study. Methods Standardized digital FAF images were obtained from 195 eyes of 129 patients with GA using confocal scanning laser ophthalmoscopy (excitation 488 nm, emission >500 nm). Areas of GA were quantified and patterns of abnormal FAF in the junctional zone were classified. Repeated FAF images were obtained over a median follow-up period of 1.80 years (interquartile range IQR, 1.28 to 3.34). Results Areas of GA (median, 7.04 mm2 at baseline; IQR, 3.12 to 10.0) showed a median enlargement of 1.52 mm2 /year (IQR, 0.81 to 2.33). Progression rates in eyes with the banded (median 1.81 mm2 /year) and the diffuse FAF pattern (1.77 mm2 /year) were significantly higher compared to eyes without FAF abnormalities (0.38 mm2 /year) and focal FAF patterns (0.81 mm2 /year, P < .0001). Within the group of the diffuse pattern, eyes with a diffuse trickling pattern could be identified that exhibited an even higher spread rate (median 3.02 mm2 /year) compared to the other diffuse types (1.67 mm2 /year, P = .001). Conclusions The results indicate that distinct phenotypic FAF patterns have an impact on disease progression in eyes with atrophic AMD and may therefore serve as prognostic determinants. The findings underscore the relevance of FAF imaging and the pathogenetic role of excessive retinal pigment epithelium (RPE) lipofuscin (LF) accumulation in GA. Natural history data and identification of high-risk characteristics will be helpful to design interventional studies aiming at slowing the spread of atrophy.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.