E-resources
PDF-
Lacinová, L’; Klugbauer, N; Hofmann, F
FEBS letters, November 06, 2002, 2002-Nov-06, 20021106, Volume: 531, Issue: 2Journal Article
Intramembrane charge movement originating from Cav3.1 (T‐type) channel expressed in HEK 293 cells was investigated. Ion current was blocked by 1 mM La3+. Charge movement was detectable for depolarizations above ∼−70 mV and saturated above +60 mV. The voltage dependence of charge movement followed a single Boltzmann function with half‐maximal activation voltage +12.9 mV and +12.3 mV and with slopes of 22.4 mV and 18.1 mV for the ON‐ and OFF‐charge movement, respectively. Inactivation of ICa by prolonged depolarization pulse did not immobilize intramembrane charge movement in the Cav3.1 channel.
