Protective Effects of Icosahydropicenic Acid Isolated from the Roots of Clerodendrum serratum (L) Moon on Experimental Allergic Asthma

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Protective Effects of Icosahydropicenic Acid Isolated from the Roots of Clerodendrum serratum (L) Moon on Experimental Allergic Asthma

Bhujbal, Santosh S; Nanda, Rabindrakumar; Ganu, Gayatri P; Jadhav, Shubangi W; Dongre, Priti R; Choudhary, Bandu; Pokale, Dipak; Patil, Manohar J

Journal of complementary & integrative medicine, 09/2010, Volume: 7, Issue: 1

Journal Article

Plant saponins are widely distributed amongst plants and have a wide range of biological properties. Icosahydropicenic acid (IHPA), a new pentacyclic triterpenoid saponin was first time isolated from the roots of Clerodendrum Serratum (L) Moon (Verbenaceae). IHPA, at the dose of 100mg/kg, showed significant protection of mast cell degraualtion (59.62%) as compared to standard sodium cromoglycate (64.48%). The compound also revealed significant inhibitory activity on histamineinduced goat tracheal chain preparation. The study provides scientific basis for its clinical use in the treatment of asthma.

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