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Kaproń, Barbara; Łuszczki, Jarogniew; Paneth, Agata; Wujec, Monika; Siwek, Agata; Karcz, Tadeusz; Mordyl, Barbara; Głuch-Lutwin, Monika; Gryboś, Anna; Nowak, Gabriel; Pająk, Karolina; Jóźwiak, Krzysztof; Tomczykowski, Adam; Plech, Tomasz
International journal of medical sciences, 01/2017, Volume: 14, Issue: 8Journal Article
Previously, it was found that 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (TP-315) effectively protects mice from maximal electroshock-induced seizures. The aim of this study was to determine possible interactions between TP-315 and different molecular targets, i.e. GABAA receptors, voltage-gated sodium channels, and human neuronal α7 and α4β2 nicotinic acetylcholine receptors. The influence of TP-315 on the viability of human hepatic HepG2 cells was also established using PrestoBlue and ToxiLight assays. It was found that the anticonvulsant activity of TP-315 results (at least partially) from its influence on voltage-gated sodium channels (VGSCs). Moreover, the title compound slightly affected the viability of human hepatic cells.
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