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Atarashi, Koji; Suda, Wataru; Luo, Chengwei; Kawaguchi, Takaaki; Motoo, Iori; Narushima, Seiko; Kiguchi, Yuya; Yasuma, Keiko; Watanabe, Eiichiro; Tanoue, Takeshi; Thaiss, Christoph A.; Sato, Mayuko; Toyooka, Kiminori; Said, Heba S.; Yamagami, Hirokazu; Rice, Scott A.; Gevers, Dirk; Johnson, Ryan C.; Segre, Julia A.; Chen, Kong; Kolls, Jay K.; Elinav, Eran; Morita, Hidetoshi; Xavier, Ramnik J.; Hattori, Masahira; Honda, Kenya
Science (American Association for the Advancement of Science), 10/2017, Volume: 358, Issue: 6361Journal Article
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.
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