E-resources
-
King, Mary-Claire; Levy-Lahad, Ephrat; Lahad, Amnon
JAMA : the journal of the American Medical Association, 09/2014, Volume: 312, Issue: 11Journal Article
Inherited mutations in BRCA1 and BRCA2 predispose to extremely high risks of breast and ovarian cancer. But these risks are not immutable. Among women who carry mutations in BRCA1 or BRCA2, surgical intervention, in particular risk-reducing salpingo-oophorectomy, reduces risk of both ovarian and breast cancer and reduces overall mortality. However, many women with mutations in these genes are identified as carriers only after their first cancer diagnosis because their family history of cancer was not sufficient to suggest genetic testing. To identify a woman as a carrier only after she develops cancer is a failure of cancer prevention. Here, King et al describe the application of the discovery of a single gene BRCA1 that causes a form of hereditary breast cancer and suggest that population-based screening of women for BRCA1 and BRCA2 should become a routine part of clinical practice.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.