A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation

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A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation

Hu, Ling; Chen, Si-Si; Zhang, Hui; Chao, Jing-Jing; Peng, Zhen-Zhen; Mao, Guo-Jiang; Hu, Liufang; Ouyang, Juan; Min, Anjie; Li, Chun-Yan

Chemical communications (Cambridge, England), 06/2024, Volume: 6, Issue: 52

Journal Article

A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO − in living cells, image ONOO − in paw edema mice and evaluate anti-inflammatory drugs. A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has long emission and large Stokes shift. TX-P can be used to visualize ONOO − in cells, image ONOO − in paw edema mice and evaluate anti-inflammatory drugs.

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