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Rao, Shan-Shan; Hu, Yin; Xie, Ping-Li; Cao, Jia; Wang, Zhen-Xing; Liu, Jiang-Hua; Yin, Hao; Huang, Jie; Tan, Yi-Juan; Luo, Juan; Luo, Ming-Jie; Tang, Si-Yuan; Chen, Tuan-Hui; Yuan, Ling-Qing; Liao, Er-Yuan; Xu, Ran; Liu, Zheng-Zhao; Chen, Chun-Yuan; Xie, Hui
Bone research, 03/2018, Volume: 6Journal Article
Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global knockout ( ) mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α (TNF-α), we determined that recombinant omentin-1 reduces the production of pro-inflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the pro-inflammatory cytokines.
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