Purpose: The intravenous or intramuscular administration of epinephrine is recommended treatment in systemic anaphylaxis. The goal was to evaluate epinephrine plasma levels after intramuscular injection into the buccinator muscle in comparison to inhaled epinephrine. Methods: In this pilot study in humans, we measured plasma epinephrine concentrations before and after epinephrine administration by intramuscular injection, or by inhalation, with intramuscular saline and intravenous epinephrine as the negative and positive controls, respectively. Results: Peak plasma epinephrine concentrations were higher after epinephrine was injected intramuscularly with a maximum plasma epinephrine concentration of 3367.2 pg/ml. After administration by inhalation epinephrine peak level was 151.89 pg/ml. Conclusions: In cases of respiratory distress when anaphylaxis is a possible cause, at first the application of epinephrine by inhalation may be of value. Manifest major cardiovascular reactions according to anaphylaxis without availability of a venous access can only be treated by titration of epinephrine intramuscularly. The buccinator muscle is a useful site for dentists involved on treatment of anaphylaxis. Key words Anaphylaxis; Epinephrine Svrha: Intravenozna ili intramuskularna primjena epinefrina preporucuje se u slucaju sistemske anafilaksije. Zadatak je bio prociieniti njegovu razinu u plazmi nakon intramuskularne primjene u misic bukcinator u odnosu prema razini nakon inhalacije. Ispitanici i postupci: U ovom eksperimentalnom istrazivaniu na ljudima mjerile su se koncentracije epinefrina prije intramuskularne primjene ili inhalacije te nakon njih, uz intramuskularnu injekciju fizioloske otopine te intravenoznu primjenu epinefrina kao negativnu i pozitivnu kontrolu. Rezultati: Najvise vriiednosti bile su nakon intramuskularne primjene--maksimalna razina u plazmi iznosila je 3367,2 pg/ml. Nakon inhalacije epinefrina razina je bila 151,89 pg/ml. Zakljucak: U slucaju respiratornog poremecaja, ako je uzrok anafilaksija, moze biti korisna inhalacijska primjena epinefrina. Kod teskih kardiovaskularnih reakcija, ako nije dostupan venski put, jedini je nacin primjene intramuskularna titracija epinefrina. Misic bukcinator korisno je mjesto za stomatologe koji se susrecu sa slucajevima anafilaksije. Kljucne rijeci anafilaksija, epinefrin