The Role of Prostaglandin E2 in Tumor-Associated Immunosuppression

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The Role of Prostaglandin E2 in Tumor-Associated Immunosuppression

Wang, Dingzhi; DuBois, Raymond N

Trends in molecular medicine, 01/2016, Volume: 22, Issue: 1

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Tumor-associated inflammation can create an immunosuppressive microenvironment allowing tumor cells to escape immunosurveillance. Inhibiting immunosuppression remains one of the major challenges in cancer immunotherapy via checkpoint inhibitors. Recent preclinical data from the Reis e Sousa group may provide a strong rationale for developing new therapeutics to subvert tumor-induced immunosuppression via prostaglandin inhibition.

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Wang, Dingzhi | DuBois, Raymond N

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