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Pajon, Rolando; Doria-Rose, Nicole A; Shen, Xiaoying; Schmidt, Stephen D; O’Dell, Sijy; McDanal, Charlene; Feng, Wenhong; Tong, Jin; Eaton, Amanda; Maglinao, Maha; Tang, Haili; Manning, Kelly E; Edara, Venkata-Viswanadh; Lai, Lilin; Ellis, Madison; Moore, Kathryn M; Floyd, Katharine; Foster, Stephanie L; Posavad, Christine M; Atmar, Robert L; Lyke, Kirsten E; Zhou, Tongqing; Wang, Lingshu; Zhang, Yi; Gaudinski, Martin R; Black, Walker P; Gordon, Ingelise; Guech, Mercy; Ledgerwood, Julie E; Misasi, John N; Widge, Alicia; Sullivan, Nancy J; Roberts, Paul C; Beigel, John H; Korber, Bette; Baden, Lindsey R; El Sahly, Hana; Chalkias, Spyros; Zhou, Honghong; Feng, Jing; Girard, Bethany; Das, Rituparna; Aunins, Anne; Edwards, Darin K; Suthar, Mehul S; Mascola, John R; Montefiori, David C
New England journal of medicine/The New England journal of medicine, 03/2022, Volume: 386, Issue: 11Journal Article
Neutralization of the omicron variant was assessed in serum samples obtained from persons who had received an mRNA-1273 booster. After the standard two-dose vaccine regimen, these titers were approximately 35 times lower than those against the D614G variant. However, boosters increased omicron neutralization by a factor of 20 — to levels that correlate with clinical resistance to infection.
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