Integration of endoplasmic reticulum signaling in health and disease

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Integration of endoplasmic reticulum signaling in health and disease

Aridor, Meir; Balch, William E

Nature medicine, 199907, 1999-Jul, 1999-7-1, 19990701, Volume: 5, Issue: 7

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Integration of endoplasmic reticulum (ER) signaling in health/disease is discussed. Change in the ER processing of cargo molecules by pathogens or inadequacies in cargo handling by the ER mechanisms in a range of diseases from cystic fibrosis to hemochromatosis and neuropathies such as Alzheimer disease shows a surprising role of the ER in cell fate control. Topics include chaperones in assisted folding in the ER and cellular control of ligands regulating ER export.

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