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Yang, D.; Chertov, O.; Bykovskaia, S. N.; Chen, Q.; Buffo, M. J.; Shogan, J.; Anderson, M.; Schröder, J. M.; Wang, J. M.; Howard, O. M. Z.; Oppenheim, J. J.
Science (American Association for the Advancement of Science), 10/1999, Volume: 286, Issue: 5439Journal Article
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human β-defensins are also chemotactic for immature dendritic cells and memory T cells. Human β-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The β-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by β-defensin. Thus, β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.
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