E-resources
Peer reviewed
Open access
-
Kaya, Emre; Yilmaz, Seval; Aksu, Feyza; Kavaklı, Ahmet
Revista científica (Universidad del Zulia. Facultad de Ciencias Veterinarias. División de Investigación), 01/2024, Volume: XXXIV, Issue: 1Journal Article
This study aims to investigate the effects of Ozone therapy used in traditional and complementary medicine on possible toxicity caused by Acetaminophen (APAP). There was no intervention in first group (control). The second group received 150 µg·kg-1 day, i.p. for three weeks of ozone, 2 g·kg-1 orally single dose APAP to third group, and APAP+Ozone to fourth group. APAP was administered on 21st day of ozone application. Malondialdehyde (MDA) levels, reduced glutathione (GSH) levels, and antioxidant enzyme activities were all measured to assess their contribution to pathogenesis of toxicity in blood tissues. Compared to the control group, the group receiving APAP showed increased MDA levels (P=0.009) and decreased GSH levels (P<0.001), as well as reduced CAT (P<0.001), GSH–Px (P<0.001) and SOD (P<0.001) enzyme activities. However, in the group treated with ozone and APAP, levels of MDA and GSH, as well as the activities of the antioxidant enzymes, were similar to those of the control group, indicating a protective effect of ozone against APAP–induced oxidative stress. In conclusion, the results of the study showed that APAP caused oxidative stress in blood tissue. The present study showed that ozone had potential protective effects against toxicity induced with APAP through various mechanisms in different cellular processes. This may be related to cytoprotective and antioxidant properties of ozone. Ozone can provide a chemical basis for some health benefits against toxicities. Ozone may be protective against APAP–induced oxidative damage. As a result, it was concluded that ozone may be a natural and effective antioxidant that can be used to reduce the toxicity caused by APAP.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.