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ZENG, Xian-ying; CHEN, Xiao-han; MA, Shu-jie; WU, Jiao-jiao; BAO, Hong-mei; PAN, Shu-xin; LIU, Yan-jing; DENG, Guo-hua; SHI, Jian-zhong; CHEN, Pu-cheng; JIANG, Yong-ping; LI, Yan-bing; HU, Jing-lei; LU, Tong; MAO, Sheng-gang; GUO, Xing-fu; LIU, Jing-li; TIAN, Guo-bin; CHEN, Hua-lan
Journal of Integrative Agriculture, 09/2020, Volume: 19, Issue: 9Journal Article
We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50–60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.
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