Cellular Integration of an Enzyme-Loaded Polymersome Nanoreactor

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Cellular Integration of an Enzyme-Loaded Polymersome Nanoreactor

van Dongen, Stijn F.M; Verdurmen, Wouter P.R; Peters, Ruud J.R.W; Nolte, Roeland J.M; Brock, Roland; van Hest, Jan C.M

Angewandte Chemie (International ed.), September 24, 2010, Volume: 49, Issue: 40

Journal Article

Cells with implants: Porous enzyme‐loaded polymersomes were constructed that display the cell‐penetrating peptide tat on their surfaces. These nanoreactors are taken up by mammalian cells through macropinocytosis. Inside the cells, the polymersomes are only partially routed to acidic compartments. Polymersomes with horseradish peroxidase as a model cargo enzyme displayed sustained intracellular activity.

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