•This paper presents a set of significant indicators for successfully reducing construction waste at the design stage.•Six significant indicators are deprived for effective implementation of waste minimization at the design stage.•The applicability and significance of the identified significant indicators are explored.•These significant indicators provide designers and project managers a useful criterion.•These can also sever as valuable references for the government to formulate related construction regulations. Construction waste minimization at the design stage is a key strategy in effective waste reduction. However, it seems that few studies focus on exploratory factors that can significantly improve the design of construction waste minimization. This paper addresses this research gap by presenting a set of critical factors that inform and improve the practice of waste minimization design, particularly in the context of Shenzhen, China. Nineteen potential factors which can influence effective waste minimization are presented based on related official guidelines, reports and literature. Top institutions in Shenzhen that have received a Grade A building design certification were surveyed through a questionnaire. From this survey, six critical factors are derived: (1) large-panel metal formworks, (2) prefabricated components, (3) fewer design modifications, (4) modular design, (5) waste reduction investment and (6) economic incentive. The applicability and significance of the identified critical factors for effectively designing waste minimization are also explored. These critical factors not only provide designers and project managers with a useful set of criteria for effective design strategies to reduce construction waste, but also serve as valuable references for the government to formulate related construction waste minimization regulations.