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Luo, Ailin; Xie, Zheng; Wang, Yue; Wang, Xuan; Li, Shan; Yan, Jing; Zhan, Gaofeng; Zhou, Zhiqiang; Zhao, Yilin; Li, Shiyong
Neuroscience and biobehavioral reviews, June 2022, 2022-Jun, 2022-06-00, 20220601, Volume: 137Journal Article
Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on personal health and put an enormous burden on the healthcare system, and increasing attention has been paid to T2D-associated cognitive dysfunction (TDACD). TDACD is characterized by cognitive dysfunction, delayed executive ability, and impeded information-processing speed. Brain imaging data suggest that extensive brain regions are affected in patients with T2D. Based on current findings, a wide spectrum of non-specific neurodegenerative mechanisms that partially overlap with the mechanisms of neurodegenerative diseases is hypothesized to be associated with TDACD. However, it remains unclear whether TDACD is a consequence of T2D or a complication that co-occurs with T2D. Theoretically, anti-diabetes methods are promising neuromodulatory approaches to reduce brain injury in patients with T2D. In this review, we summarize potential mechanisms underlying TDACD and promising neurotropic effects of anti-diabetes methods and some neuroprotective natural compounds. Constructing screening or diagnostic tools and developing targeted treatment and preventive strategies would be expected to reduce the burden of TDACD. •TDACD is a highly prevalent and age-dependent complication of T2D.•Extensive but nonspecific changes in the brain underlie TDACD.•Improved healthy lifestyle and GLP-1RAs might mitigate TDACD.
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