Uplifting mountains are denudated by gravitational deformation, landslides, and glacial or fluvial erosion. We investigated the response of valley slopes to glacial and fluvial erosion along the Kali Gandaki (KG) River, one of the largest rivers that flows through the High Himalaya southward from Tibet to India and diagonally cuts the strikes of gneiss and slate foliations. Satellite images with 2.5 m resolution and 5-m Digital Elevation Models (DEMs) were used for the investigation. Within a 20-km reach of the KG River, we found a series of 11 landslides, which vary from a total area of 0.58 to 12 million m2 each. The foliations generally strike NW–SE and dip at 30° to 50° to the NE, so the left bank slopes are anaclinal and the right bank slopes are cataclinal. On the cataclinal slopes, buckling of beds occurs, and gradual deformation proceeds in slate and two-mica gneiss, while in the more competent calc gneiss, buckling deformation develops into a rock avalanche. Such rock avalanches are represented by the largest Dhampu-Chhoya landslide, which once blocked the KG River and drastically changed the river morphology. Anaclinal slopes of two-mica gneiss were toppled and transformed into rock avalanches on three slopes. The KG River has a prominent fluvial knickpoint, which is currently at an elevation of 1800 m, and it has slope breaks on the left bank that are 200–400 m above the riverbed downstream of the knickpoint. Toppling was observed on slopes higher than slope breaks, which suggests that toppling began before the formation of slope breaks by fluvial incision and that the lower slopes did not adapt to the younger fluvial incision. In contrast, slope breaks are scarcely found on the right bank, probably because slow-moving DGSDs, which followed the river incision, erased them. •The Himalayan mountains respond to erosion based on geological structures.•Buckling and gradual deformation proceed on dip slopes of incompetent rock.•Buckling of competent rock develops into catastrophic failure.•On anaclinal slopes, toppling and catastrophic failure occur.•Upstream migration of a fluvial knickpoint induced a series of mass movements.•Glacial erosion and deglaciation destabilized the feet of dip slopes, inducing buckling deformation.