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Hu, Yong; Niemeyer, Christof M.
Advanced materials (Weinheim), 06/2019, Volume: 31, Issue: 26Journal Article
In the past 35 years, DNA nanotechnology has grown to a highly innovative and vibrant field of research at the interface of chemistry, materials science, biotechnology, and nanotechnology. Herein, a short summary of the state of research in various subdisciplines of DNA nanotechnology, ranging from pure “structural DNA nanotechnology” over protein–DNA assemblies, nanoparticle‐based DNA materials, and DNA polymers to DNA surface technology is given. The survey shows that these subdisciplines are growing ever closer together and suggests that this integration is essential in order to initiate the next phase of development. With the increasing implementation of machine‐based approaches in microfluidics, robotics, and data‐driven science, DNA‐material systems will emerge that could be suitable for applications in sensor technology, photonics, as interfaces between technical systems and living organisms, or for biomimetic fabrication processes. DNA nanotechnology is on its way to creating integrated functional systems for material research, life sciences, and high‐end technology. The current state of various subdisciplines of DNA nanotechnology is summarized, ranging from “structural DNA nanotechnology” over protein‐ and nanoparticle‐modified DNA assemblies, to DNA polymers and DNA surface technology, respectively.
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