Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic

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Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic

De Borggraeve, Wim M; Rombouts, Frederik J.R; Van der Eycken, Erik V; Toppet, Suzanne M; Hoornaert, Georges J

Tetrahedron letters, 08/2001, Volume: 42, Issue: 33

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Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels–Alder strategy. The β-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy. Graphic

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De Borggraeve, Wim M | Rombouts, Frederik J.R | Van der Eycken, Erik V | Toppet, Suzanne M | Hoornaert, Georges J

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