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Pan, Wenhao; Qi, Xiaoliang; Xiang, Yajing; You, Shengye; Cai, Erya; Gao, Teng; Tong, Xianqin; Hu, Rongdang; Shen, Jianliang; Deng, Hui
International journal of biological macromolecules, 01/2022, Volume: 195Journal Article
The wound healing process of the diabetic wound is often hindered by excessive oxygen free radicals and infection. An ideal wound dressing should possess great reactive oxygen species (ROS) scavenging property and considerable antibacterial ability. In this study, we facilely constructed a novel hydrogel dressing with excellent ROS scavenging property and outstanding antibacterial performance by introducing tannic acid (TA) into quaternized chitosan (QCS) matrix. Attributing to the suitable physical crosslinking between TA and QCS, this QCS/TA hydrogel was endowed with injectable and self-healing properties, which could avoid the various external squeezing on the irregular shape by wound dressing. The results showed that it could promote coagulation, suppress inflammation and expedite collagen deposition in the skin defect model of diabetic rats. This study provides a facile and convenient method for constructing injectable hydrogel dressing, which has application potentials in the clinical management of diabetic wounds. •An injectable hydrogel (QT) composed of quaternized chitosan and tannic acid was designed.•One-step fabrication of QT hydrogel was achieved via alkali neutralization strategy.•QT hydrogel possessed robust antibacterial and ROS scavenging capabilities.•QT hydrogel significantly accelerated skin tissue regeneration in diabetic wounds.
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