Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection

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Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection

Shook, Lydia L; Atyeo, Caroline G; Yonker, Lael M; Fasano, Alessio; Gray, Kathryn J; Alter, Galit; Edlow, Andrea G

JAMA, 03/2022, Volume: 327, Issue: 11

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COVID-19 vaccination in pregnancy generates functional anti-spike (anti-S) IgG antibodies in maternal circulation that are detectable in umbilical cord blood at birth and can protect newborns and infants from COVID-19. Anti-S IgG titers in the umbilical cord are correlated with maternal titers and are highest after late second and early third trimester vaccination. Here, Shook et al characterized the persistence of vaccine-induced maternal anti-S IgG in infant blood and compared persistence of infant anti-S IgG after maternal vaccination vs natural infection.

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