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Zheng, Yan‐Long; Newman, Stephen G.
Angewandte Chemie International Edition, December 9, 2019, Volume: 58, Issue: 50Journal Article
While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross‐coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni‐catalyzed Heck‐type reactions through the challenging cleavage of the C(acyl)−O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ‐NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl‐retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used. Partner up: Methyl esters are shown to be viable cross‐coupling partners in intramolecular cyclization reactions with a tethered olefin. Both a boronic acid and mild hydride donors can be used in this nickel‐catalyzed reaction, providing differentially substituted indanone products.
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