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Gruene, Tim; Wennmacher, Julian T. C.; Zaubitzer, Christan; Holstein, Julian J.; Heidler, Jonas; Fecteau‐Lefebvre, Ariane; De Carlo, Sacha; Müller, Elisabeth; Goldie, Kenneth N.; Regeni, Irene; Li, Teng; Santiso‐Quinones, Gustavo; Steinfeld, Gunther; Handschin, Stephan; van Genderen, Eric; van Bokhoven, Jeroen A.; Clever, Guido H.; Pantelic, Radosav
Angewandte Chemie (International ed.), December 10, 2018, Volume: 57, Issue: 50Journal Article
Chemists of all fields currently publish about 50 000 crystal structures per year, the vast majority of which are X‐ray structures. We determined two molecular structures by employing electron rather than X‐ray diffraction. For this purpose, an EIGER hybrid pixel detector was fitted to a transmission electron microscope, yielding an electron diffractometer. The structure of a new methylene blue derivative was determined at 0.9 Å resolution from a crystal smaller than 1×2 μm2. Several thousand active pharmaceutical ingredients (APIs) are only available as submicrocrystalline powders. To illustrate the potential of electron crystallography for the pharmaceutical industry, we also determined the structure of an API from its pill. We demonstrate that electron crystallography complements X‐ray crystallography and is the technique of choice for all unsolved cases in which submicrometer‐sized crystals were the limiting factor. Electrons instead of X‐rays: An electron diffractometer was tailored and employed for de novo structure determination from submicrometer‐sized crystals. A new methylene blue derivative was analysed together with a microcrystalline extract of an active pharmaceutical ingredient from a pill. The results obtained on submicrometer‐sized samples complement X‐ray crystallography.
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