Hydrogels with wet adhesion are promising interfacial adhesive materials; however, their adhesion in water, oil, or organic solvents remains a major challenge. To address this, a pressure‐sensitive P(AAm‐co‐C18)/PTA‐Fe hydrogel is fabricated, which exhibits robust adhesion to various substrates in both aqueous solutions and oil environments. It is demonstrated that the key to wet adhesion under liquid conditions is the removal of the interfacial liquid, which can be achieved through rational molecular composition regulation. By complexing with hydrophilic polymer networks, phosphotungstic acid (PTA) is introduced into the hydrogel network as a physical cross‐linker and anchor point to improve the cohesion strength and drive the migration of polymer chains. The migration and rearrangement of hydrophilic and hydrophobic polymer chains on the hydrogel surface are induced by the electrostatic interactions of Fe3+, which create a surface with interfacial water‐ and oil‐removing properties. By co‐regulating the hydrophilic and hydrophobic polymer chains, the P(AAm‐co‐C18)/PTA‐Fe hydrogel is able to act as a pressure‐sensitive adhesive under water and oils with adhesion strength of 92.6 and 90.0 kPa, respectively. It is anticipated that this regulation strategy for polymer chains will promote the development of wet adhesion hydrogels, which can have a wide range of applications. A pressure‐sensitive hydrogel exhibits robust adhesion in aqueous solution and oil environments by electrostatic‐induced hydrophilic and hydrophobic polymer chains migration and rearrangement, which realizes the removal of the interfacial liquid layer and the effective interfacial bonding during wet adhesion. This polymer‐chains‐regulated hydrogel provides a new strategy for adhesion in liquid environments, broadening the application scenarios of adhesives.