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García‐Jacobo, Rocío E.; Uresti‐Rivera, Edith E.; Portales‐Pérez, Diana P.; González‐Amaro, Roberto; Lara‐Ramírez, Edgar E.; Enciso‐Moreno, José A.; García‐Hernández, Mariana H.
Clinical and experimental pharmacology & physiology, December 2019, 2019-12-00, 20191201, Volume: 46, Issue: 12Journal Article
The pathogenesis of type 2 diabetes (T2D) is associated with a progressive loss of pancreatic β‐cell mass. It is known that miR‐146a, miR‐34a, and miR‐375 are involved in β‐cell functionality. In this work, we evaluated the levels of these miRNAs in normal‐glycaemic individuals, pre‐diabetic, and T2D patients in relation to β‐cell functionality, insulin resistance, and metabolic parameters. The relative expression of the miRNAs was evaluated in serum samples by real‐time polymerase chain reaction. In a principal component analysis, we observed that T2D patients and pre‐diabetic individuals were not associated with β‐cell functionality. However, in a correlation matrix analysis, we detected that miR‐34a was related to miR‐146a and insulin resistance. The relative expression of miR‐375 was correlated with cholesterol and low‐density lipoprotein levels. A decrease of β‐cell function in pre‐diabetic individuals and T2D patients was observed. The insulin resistance was higher in pre‐diabetic individuals and T2D patients. The relative expression of miR‐146a in pre‐diabetic individuals, T2D patients with insulin treatment, and T2D patients with nephropathy and diabetic foot was decreased. In addition, miR‐34a was increased in T2D patients who were overweight and obese. The relative expression of miR‐375 was increased in T2D patients with poor glycaemic control, while a decrease was seen in T2D patients with nephropathy and diabetic foot. Circulating miR‐375, miR‐34a, and miR‐146a were not associated with β‐cell functionality, but their expression was differentially affected by glycaemia, obesity, insulin treatment, and the presence of nephropathy and diabetic foot.
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