The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

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The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

Kildegaard, Helene Faustrup; Baycin-Hizal, Deniz; Lewis, Nathan E; Betenbaugh, Michael J

Current opinion in biotechnology, 12/2013, Volume: 24, Issue: 6

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Graphical abstract Highlights ► The new CHO-K1 genome sequence has facilitated advanced systems biology analyses. ► Transcriptomics and proteomics advances provide molecular readouts of CHO physiology. ► ‘Omics data sets are also being used to facilitate CHO cell and metabolic engineering. ► ‘Omics data are integrated into mathematical models to describe CHO phenotypes. ► Systems biology enhances and accelerates improvements in CHO bioprocessing capacity.

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Kildegaard, Helene Faustrup | Baycin-Hizal, Deniz | Lewis, Nathan E | Betenbaugh, Michael J

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