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Li, Qiyao; Li, Ying; Min, Tianliang; Gong, Junyi; Du, Lili; Phillips, David Lee; Liu, Junkai; Lam, Jacky W. Y.; Sung, Herman H. Y.; Williams, Ian D.; Kwok, Ryan T. K.; Ho, Chun Loong; Li, Kai; Wang, Jianguo; Tang, Ben Zhong
Angewandte Chemie International Edition, June 8, 2020, Volume: 59, Issue: 24Journal Article
Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small ΔEST, 4TPA‐BQ shows a satisfactorily high 1O2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications. Millennium bug: A simple and highly efficient photosensitizer, called 4TPA‐BQ, operates by aggregation‐induced emission. A broad‐spectrum and potent antibacterial activity was attained after incubating 4TPA‐BQ with pathogens for 15 minutes. Upon lengthening of the incubation time to 12 hours, photodynamic therapy with 4TPA‐BQ targeted cancer cells and presented low toxicity to normal cells.
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