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Márquez-González, Horacio; Hernández-Vásquez, Jose Gustavo; Del Valle-Lom, Montserrat; Yáñez-Gutiérrez, Lucelli; Klünder-Klünder, Miguel; Almeida-Gutiérrez, Eduardo; Koretzky, Solange Gabriela
Life, 12/2021, Volume: 11, Issue: 12Journal Article
The Fontan procedure (FP) is the standard surgical treatment for Univentricular heart diseases. Over time, the Fontan system fails, leading to pathologies such as protein-losing enteropathy (PLE), plastic bronchitis (PB), and heart failure (HF). FP should be considered as a transitional step to the final treatment: heart transplantation (HT). This systematic review and meta-analysis aims to establish the risk of death following HT according to the presence of FP complications. There was a total of 691 transplanted patients in the 18 articles, immediate survival 88% ( = 448), survival from 1 to 5 years of 78% ( = 427) and survival from 5.1 to 10 years of 69% ( = 208), >10 years 61% ( = 109). The relative risk (RR) was 1.12 for PLE (95% confidence interval CI = 0.89-1.40, = 0.34), 1.03 for HF (0.7-1.51, = 0.88), 0.70 for Arrhythmias (0.39-1.24, = 0.22), 0.46 for PB (0.08-2.72, = 0.39), and 5.81 for CKD (1.70-19.88, = 0.005). In patients with two or more failures, the RR was 1.94 (0.99-3.81, = 0.05). After FP, the risk of death after HT is associated with CKD and with the presence of two or more failures.
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