E-resources
Peer reviewed
Open access
-
Lin, X.-F.; Ten, X.-L.; Tang, X.-B.; Chen, J.
Acta neurologica Scandinavica, March 2016, Volume: 133, Issue: 3Journal Article
Background Soluble CD40 ligand (sCD40L) is associated with inflammation. This study aimed to assess the prognostic value of sCD40L for clinical outcomes of acute intracerebral hemorrhage (ICH) patients. Materials and methods The serum sCD40L levels of 110 patients and 110 age‐ and gender‐matched healthy controls were measured using sandwich immunoassays. The relationships between serum sCD40L levels and 1‐week mortality, 6‐month mortality, 6‐month overall survival, 6‐month unfavorable outcome (modified Rankin Scale score >2), and ICH severity including hematoma volume and National Institutes of Health Stroke Scale (NIHSS) score were assessed using multivariate analysis. Results Compared with healthy controls, ICH patients had higher serum sCD40L levels. Serum sCD40L levels were correlated positively with hematoma volumes and NIHSS scores using a multivariate linear regression. Multivariate analysis results indicated that sCD40L was identified an independent predictor of 1‐week mortality, 6‐month mortality, 6‐month unfavorable outcome and 6‐month overall survival. sCD40L also showed high predictive performances for 1‐week mortality, 6‐month mortality and 6‐month unfavorable outcome based on receiver operating characteristic curve. Conclusions Elevated serum sCD40L levels are independently associated with ICH severity and clinical outcomes. And sCD40L has potential to be a good prognostic biomarker of ICH.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.