E-resources
Peer reviewed
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Munn, David H.; Sharma, Madhav D.; Lee, Jeffrey R.; Jhaver, Kanchan G.; Johnson, Theodore S.; Keskin, Derin B.; Marshall, Brendan; Chandler, Phillip; Antonia, Scott J.; Burgess, Russell; Slingluff, Craig L.; Mellor, Andrew L.
Science (American Association for the Advancement of Science), 09/2002, Volume: 297, Issue: 5588Journal Article
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature $CD123^+ DCs$. $IDO^+ DCs$ could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
