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Elsharkawy, Sherif; Al-Jawad, Maisoon; Pantano, Maria F; Tejeda-Montes, Esther; Mehta, Khushbu; Jamal, Hasan; Agarwal, Shweta; Shuturminska, Kseniya; Rice, Alistair; Tarakina, Nadezda V; Wilson, Rory M; Bushby, Andy J; Alonso, Matilde; Rodriguez-Cabello, Jose C; Barbieri, Ettore; Del Río Hernández, Armando; Stevens, Molly M; Pugno, Nicola M; Anderson, Paul; Mata, Alvaro
Nature communications, 06/2018, Volume: 9, Issue: 1Journal Article
A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.
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