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Pan, Jia-Wern; Zabidi, Muhammad Mamduh Ahmad; Ng, Pei-Sze; Meng, Mei-Yee; Hasan, Siti Norhidayu; Sandey, Bethan; Sammut, Stephen-John; Yip, Cheng-Har; Rajadurai, Pathmanathan; Rueda, Oscar M; Caldas, Carlos; Chin, Suet-Feung; Teo, Soo-Hwang
Nature communications, 12/2020, Volume: 11, Issue: 1Journal Article
Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain understudied. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women. Compared to breast tumours in Caucasian women, we show an increased prevalence of HER2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumours. We also observe elevated immune scores in Asian breast tumours, suggesting potential clinical response to immune checkpoint inhibitors. Whilst HER2-subtype and enriched immune score are associated with improved survival, presence of TP53 somatic mutations is associated with poorer survival in ER+ tumours. Taken together, these population differences unveil opportunities to improve the understanding of this disease and lay the foundation for precision medicine in different populations.
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