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Kang, Yin-Feng; Sun, Cong; Sun, Jing; Xie, Chu; Zhuang, Zhen; Xu, Hui-Qin; Liu, Zheng; Liu, Yi-Hao; Peng, Sui; Yuan, Run-Yu; Zhao, Jin-Cun; Zeng, Mu-Sheng
Nature communications, 05/2022, Volume: 13, Issue: 1Journal Article
Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike protein. Here, we design a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs. The mosaic nanoparticle elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain. Notably, it provides protection against infection with prototype and B.1.351 strains in mice. These results provide a proof of principle for the development of multivalent vaccines against pandemic and potential pre-emergent SARS-CoV-2 variants.
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