Let M be a type II1 von Neumann factor and let S(M) be the associated Murray-von Neumann algebra of all measurable operators affiliated to M. We extend a result of Kadison and Liu 30 by showing that any derivation from S(M) into an M-bimodule B⊊S(M) is trivial. In the special case, when M is the hyperfinite type II1-factor R, we introduce the algebra AD(R), a noncommutative analogue of the algebra of all almost everywhere approximately differentiable functions on 0,1 and show that it is a proper subalgebra of S(R). This algebra is strictly larger than the corresponding ring of continuous geometry introduced by von Neumann. Further, we establish that the classical approximate derivative on (classes of) Lebesgue measurable functions on 0,1 admits an extension to a derivation from AD(R) into S(R), which fails to be spatial. Finally, we show that for a Cartan masa A in a hyperfinite II1-factor R there exists a derivation δ from A into S(A) which does not admit an extension up to a derivation from R to S(R).